Browsing by Author "KANIA ADELIA HESTY KIRANI"

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    Anti-Migration Effect of Aaptamine on HCC-1954 HER2 Positive Breast Cancer Cells
    (2023-07-14) KANIA ADELIA HESTY KIRANI; Resti Gradia Dwiwina; Muhammad Hasan Bashari
    Objective : This study aims to analyze aaptamine’s antimigration effect against HCC-1954 cell line, a trastuzumab-resistant HER2 positive breast cancer cells, through wound healing assay. Methods : HCC-1954 HER2 positive breast cancer cells. Aaptamine (8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine). MTT Assay were done to assess cytotoxicity of aaptamine. Wound healing assay is used to determine antimigration effect. Results : This study shows aaptamine’s capability of antimigration effect. Gap closure is compared between control group and IC5, IC10, and IC25 at 72 hours. Compared to control, results show migration area is smaller at IC25, but bigger at IC5 and IC10 though not significantly. Conclusion : Aaptamine inhibits HCC-1954 migration at IC25 though not statistically significant from control group.