The Role of HBOT on Pulp Capping Treatment in Enhancing TGF-β Levels: Scoping Review
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Date
2022-07-11
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Abstract
Introduction: Deep caries could harm the vitality of the pulp, so it is necessary to
protect the pulp with pulp capping procedure. Pulp capping material will release
growth factors, one of it is TGF-β which plays a role in pulp tissue repair.
Hyperbaric Oxygen Therapy (HBOT) is a treatment that can be used as an adjunct
therapy in wound healing. TGF-β levels can be increased by HBOT procedure. This
study aimed to determine the role of HBOT on the success of pulp capping treatment
in terms of increasing levels of growth factor TGF-β. Methods: A scoping review
was conducted refers to PRISMA Extension for Scoping Reviews (PRISMA-ScR)
Protocols through 4 databases included PubMed, Science Direct, Wiley Online
Library and Google Scholar. Inclusion and exclusion criteria according to the
Population, Concept, and Context (PCC) framework. Results: A total 6 articles
showed an enhancing in TGF-β levels after HBOT with difference of HBOT
treatment, other treatment, and measurement of TGF-β expression. Conclusions:
Administration of HBOT will increase levels of TGF-β growth factor in the process
of tissue repair. Thus, has the potential to increase the success of pulp capping
treatment in terms of increasing levels of TGF-β growth factor.
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Keywords
pulp capping, TGF-β, hyperbaric oxygen therapy