STUDI KOMPUTASI 6-GINGEROL, GALANGIN, DAN KAEMPFEROL DARI TANAMAN SUKU ZINGIBERACEAE SEBAGAI INHIBITOR TIROSINASE DAN ALPHA-MELANOCYTE STIMULATING HORMONE

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dc.contributor.advisorTidak ada Data Dosen
dc.contributor.advisorTidak ada Data Dosen
dc.contributor.authorFRIDE RINDU ALAMI
dc.date.accessioned2024-05-22T07:38:38Z
dc.date.available2024-05-22T07:38:38Z
dc.date.issued2012-08-09
dc.description.abstractTirosinase dan alpha melanocyte stimulating hormone (α-MSH) berperan dalam pigmentasi kulit sebagai pengatur biosintesis melanin dan sebagai modulator ekspresi tirosinase. Peningkatan aktivitas enzim tirosinase dan α-MSH dapat menyebabkan hiperpigmentasi kulit. Senyawa 6-gingerol dan kaempferol dari jahe (Zingiber officinale Roscoe.), serta galangin dari rimpang lengkuas (Alpinia officinarum Hance.), telah terbukti secara empiris dan in vitro memiliki aktivitas antioksidan dan penghambatan tirosinase. Docking molekul dilakukan untuk memvisualisasikan interaksi ketiga senyawa tersebut dengan kantung aktif tirosinase dan α-MSH. Metode docking juga digunakan untuk memprediksi aktivitas ketiganya sebagai inhibitor tirosinase dan α-MSH dibandingkan dengan arbutin, asam kojik, dan hidrokuinon. Berturut-turut inhibitor tirosinase terbaik adalah kaempferol (2,7 µM), galangin (6,3 µM), dan 6-gingerol (110,5 µM), sedangkan untuk inhibitor α-MSH adalah galangin(836,8 µM), 6-gingerol (880,2 µM), dan kaempferol (990,6 µM). Dengan demikian, ketiga senyawa lebih mudah berinteraksi dengan tirosinase dibandingkan α-MSH, interaksi terbaik ditunjukkan oleh kaempferol. Ketiga senyawa kecuali 6-gingerol mempunyai konstanta inhibisi tirosinase lebih baik dibandingkan arbutin, asam kojik, dan hidrokuinon. The roles of tyrosinase and alpha-melanocyte stimulating hormone (α-MSH) in skin pigmentation are as melanin biosynthesis regulator and as tyrosinase raising level modulator. The increasing of tyrosinase and α-MSH activity can cause skin hyperpigmentation. 6-gingerol and kaempferol from ginger (Zingiber officinale Roscoe.), as well as galangin from galangale (Alpinia officinarum Hance.), have been proven empirical and in vitro to show antioxidant and tyrosinase inhibitor activity. Molecular docking was performed to visualize the interaction of those compounds with the macromolecules. The docking method was also used to predict the activity of those compounds as tyrosinase and alpha-MSH inhibitors compared with arbutin, kojic acid, and hydroquinone.In a series, the best tyrosinase inhibitor are kaempferol (2.7 µM), galangin (6.27 µM), dan 6-gingerol (110.5 µM), whereas for α-MSH inhibitor activity are galangin(836.78 µM), 6-gingerol (880.22 µM), dan kaempferol (990.56 µM). So that, the compounds are easier to interact with tirosinase compared to α-MSH, the best interaction is shown by kaempferol. The three compounds except 6-gingerol have tyrosinase inhibition constant better than arbutin, kojic acid, and hydroquinone.Keywords: 6-gingerol, galangin, kaempferol, tyrosinase, α-MSH, molecular docking
dc.identifier.urihttps://repository.unpad.ac.id/handle/kandaga/260110080013
dc.subject6-gingerol
dc.subjectgalangin
dc.subjectkaempferol
dc.titleSTUDI KOMPUTASI 6-GINGEROL, GALANGIN, DAN KAEMPFEROL DARI TANAMAN SUKU ZINGIBERACEAE SEBAGAI INHIBITOR TIROSINASE DAN ALPHA-MELANOCYTE STIMULATING HORMONE

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