ANALISIS ANDROGRAFOLID DARI INFUSA DAUN SAMBILOTO (Andrographis paniculata Nees) PADA HATI KELINCI SEHAT
| dc.contributor.advisor | Tidak ada Data Dosen | |
| dc.contributor.advisor | Tidak ada Data Dosen | |
| dc.contributor.author | MELYSA AFDILA PUTRI | |
| dc.date.accessioned | 2024-05-22T07:38:37Z | |
| dc.date.available | 2024-05-22T07:38:37Z | |
| dc.date.issued | 2012-08-06 | |
| dc.description.abstract | Sambiloto (Andrographis paniculata Nees) merupakan salah satu tanaman yang banyak digunakan sebagai obat herbal. Selain itu, sambiloto juga digunakan untuk pemeliharaan kesehatan atau pencegahan penyakit, dimana masyarakat mengkonsumsi sambiloto dalam keadaan sehat. Dalam sambiloto, senyawa aktif utamanya adalah andrografolid. Penelitian ini dilakukan untuk mengetahui profil metabolisme (kadar per satuan waktu) andrografolid dari infusa daun sambiloto di dalam hati kelinci sehat. Empat belas ekor kelinci masing-masing diberi infusa daun sambiloto sebanyak 7 mL/kg BB secara oral. Organ hati diambil pada interval waktu 0,0; 0,5; 1,0; 1,5; 2,0; 3,0; dan 5,0 jam setelah pemberian infusa. Kadar andrografolid dalam organ hati dianalisis dengan Kromatografi Cair Kinerja Tinggi dengan menggunakan kolom C-18, fase gerak metanol:air suling ganda (55:45) dengan laju alir 1 mL/menit, dan detektor UV panjang gelombang 222 nm. Profil metabolisme yang diperoleh menunjukkan bahwa andrografolid dari infusa daun sambiloto dimetabolisme di dalam hati setelah 1,5 jam. Kadar andrografolid di dalam hati sebesar 0,004-0,005 ppm pada 2 jam. Sambiloto (Andrographis paniculata Nees) is one of the most widely used as herbal medicines. In addition, sambiloto is also used for health maintenance or disease prevention, in which people consume sambiloto in a good condition. In sambiloto, the main active compound is Andrographolide. This study was conducted to determine the metabolism profile (levels per unit time) Andrographolide from infusion of sambiloto’s leaf in the liver of healthy rabbits. Fourteen rabbits were each given the infusion of sambiloto’s leaf as much as 7 mL/kg of body weight orally. Livers were taken at time intervals 0.0; 0.5; 1.0; 1.5; 2.0; 3.0; and 5.0 hours after infusion administration. Andrographolide levels in the liver were analyzed by High Performance Liquid Chromatography using C-18 column, mobile phase of methanol: double distilled water (55:45) with flow rate of 1 mL / min, and UV detector wavelength of 222 nm. Metabolism profiles obtained show that Andrographolide from infusion of sambiloto’s leaf is metabolized in the liver after 1.5 hours. Andrographolide levels in the liver of 0.004-0.005 ppm at 2 hours.Key words: Sambiloto, andrographolide, infusion, metabolism, liver | |
| dc.identifier.uri | https://repository.unpad.ac.id/handle/kandaga/260110080012 | |
| dc.subject | Sambiloto | |
| dc.subject | andrografolid | |
| dc.subject | infusa | |
| dc.title | ANALISIS ANDROGRAFOLID DARI INFUSA DAUN SAMBILOTO (Andrographis paniculata Nees) PADA HATI KELINCI SEHAT |
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