EFEK HEPATOPROTEKTIF INFUSA DAUN SUKUN (Artocarpus altilis) PADA TIKUS YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) DENGAN INDIKATOR KADAR SGPT
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Date
2012-07-31
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Abstract
Hati adalah organ yang sering
terpapar oleh substansi
toksik maupun produk metabolismnya seperti
radikal bebas yang dapat menyebabkan kerusakan membran sel hati sehingga mengakibatkan peningkatan
kadar enzim hati seperti SGPT di dalam darah.Kerusakan hati dapat dihambat dengan pelbagai zat yang bersifat hepatoprotektor
seperti antioksidan yang mudah didapat dari sumber alam seperti daun sukun (Artocarpus altilis).Penelitian bertujuan untuk
mengetahui apakah infusa daun sukun mempunyai efek hepatoprotektif dengan menghambat
kenaikan kadar SGPT pada tikus yang diinduksi CCl4.
Penelitian eksperimental
laboratorik dengan
rancangan acak lengkap terhadap 15 ekor tikus jantan galur
Wistar yang dibagi menjadi 3 kelompok. Kelompok I (kontrol negatif) hanya
mendapat minum dan makanan standar, kelompok II (kontrol positif) yang diinduksi 8 ml/kgBB CCl4
intraperitoneal pada hari ke-6, dan kelompok
III (perlakuan) mendapat infusa daun sukun 4,75% melalui gastric tube selama 6 hari dan diinduksi 8 ml/kgBB CCl4
intraperitoneal pada hari ke-6. Pada hari ke-9 dilakukan pengukuran kadar SGPT
pada semua kelompok. Hasilnya dianalisis dengan uji ANOVA dan dilanjutkan
dengan uji Dunnet T3.
Hasil penelitian
menunjukkan bahwa terdapatperbedaan bermakna (p 0,05) antara rata-rata
kadar SGPT padakelompok I dan III.
Kesimpulan
penelitian ini adalah infusa daun sukun mempunyai efek
hepatoprotektifdengan menghambat
kenaikan kadar SGPTtikus yang diinduksi CCl4.Liver is an
organ that often exposed
to toxic substances or its metabolism products like free radicals
that can cause liver cell membrane damage resulting in elevated level of liver
enzymes such asSGPT in the blood.Liver damagecan bepreventedbyvarioussubstances whicharehepatoprotectorsuch asantioxidantsare easy
to getfromnaturalsourceslike leaves
ofbreadfruit(Artocarpus altilis). The aim of this study is to determine whether the
infusion of breadfruit leaves have the hepatoprotective effect byprevents the increase of SPGT level in the ratinduced with CCl4.
A
laboratory experimental study with randomized complete design has
been conducted on 15 male Wistar rats whichdivided into 3
groups. Group I (negative control) only receive water and standard food, group
II (positive control) were induced by 8 ml/kgBW CCl4 intraperitoneally on 6th
day, and group III (treatment) were given 4.75% breadfruit leaves
infusion through gastric tube for 6 days and were induced by 8 ml/kgBW CCl4
intraperitoneally on 6th day. On 9th day SPGT level measurement
was done for all groups. The results were analyzed using ANOVA test and Dunnet
T3 test subsequently.
The results showed that there were
significant differences (p of SGPTin group II with group I and
III. Meanwhile, there were no significant differences (p> 0.05) between
average levels of SGPT in group I and
III.
The conclusion of this research is
breadfruit leaves infusion have
hepatoprotective effect by prevents the increase of SPGT level in the ratinduced with CCl4.
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Keywords
daun sukun, hepatoprotektif, CCl4