Comparison of TGF-β1 in Corneal Laceration with or without Aloe vera Gel Treatment

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dc.contributor.advisorNur Atik
dc.contributor.advisorRaden Angga Kartiwa
dc.contributor.authorMUHAMAD ARIF RACHMAN SURURI
dc.date.accessioned2024-05-18T05:31:26Z
dc.date.available2024-05-18T05:31:26Z
dc.date.issued2017
dc.description.abstractCorneal stromal wound healing is slower than other connective tissue, is thought to be partly controlled by various matrix metalloproteinases. Transforming Growth Factors – βeta 1 (TGF-β1) appears in the three main phases of the wound healing process as a mediator and plays a role in the final matrix formation phase. Aloe vera has a glucomannan component, which can accelerate the production of TGF-β. This study aims to compare the expression of TGF-β in corneal lamellar lacerations in mice treated with and without Aloe vera gel therapy. This was an experimental study using mice model treated with a corneal laceration wound. The sample size obtained was 20 samples, which were grouped into four types of treatment. TGF-β1 immunohistochemistry expression on the first day in the strong positive category showed 10% without gel and 50% with gel. In contrast, the same category on the third day showed 10% without gel and 90% with gel. There were two significant differences upon these two days (p = 0.013, p = 0.003). Apart from the two groups treated with Aloe vera gel, the results were then compared between the first and third days (p = 0.141). This result is to determine the expression of TGF-β1 on wound healing time. Assessment of TGF-β1 expression in the healing process of laceration in mice was subjected to Aloe vera gel showing higher results.
dc.identifier.urihttps://repository.unpad.ac.id/handle/kandaga/130110170015
dc.subjectActive component
dc.subjectCorneal healing process
dc.subjectImmunohistochemistry TGF-β1 expression
dc.titleComparison of TGF-β1 in Corneal Laceration with or without Aloe vera Gel Treatment

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