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AAPTAMINE EFFECT OF CANCER CELL GROWTH INHIBITION ON 3-DIMENSIONAL MODEL BREAST CANCER CELLS
(2023-07-14) ILHAM IZDIHAR AINAN ZAHRA; Muhammad Hasan Bashari; Savira Ekawardhani
Breast cancer remains as global health challange, representing the most commonly diagnosed cancer in woman worldwide. Breast cancer ranks first as the highest incidence of cancer surpassing lung cancer in Indonesia. HER2+ as one of the subtype of breast cancer accounts for poor prognosis in patients as well as developing resistance to first line treatment known such as trastuzumab. Aaptamine is secondary metabolite compound derived from Aaptos suberitoides has been discovered to have anti-cancer activity. This study aimed to investigate the cancer cell growth inhibition effect on 3D breast cancer cell culture (spheroid assay). HCC1954 breast cancer cell line were used as spheroids representing trastuzumab-resistant HER2+ breast cancer cell. Spheroids were grouped into negative control and serial treatment group consisting 40 µM, 80 µM, and 120 µM concentration of aaptamine. Cancer cell growth inhibition was analyzed using spheroid growth assay observed under inverted microscope with 100x magnification on day 0, 4th and 8th. This study revealed that there was statistically significant size reduction of spheroids treated with 80 µM and 120 µM compared to control group on 8th day (p value < 0.05). In conclusion, aaptamine inhibited cell growth on 3D cell culture of trastuzumab-resistant HER2+ breast cancer cells.
ABNORMAL MENSTRUAL PATTERNS IN PATIENTS WITH PULMONARY TUBERCULOSIS
(2023-03-27) ALEESHA ZALICA; Mulya Nusa Amrullah Ritonga; Iceu Dimas Kulsum
Several studies have shown abnormal uterine bleeding (AUB) in pulmonary tuberculosis (TB) patients. Even so, Indonesia, as a country with high TB cases, does not seem to have much data regarding this disorder. This study aims to provide an overview of menstrual patterns in pulmonary TB patients as a consideration for clinicians to evaluate. This was a descriptive cross-sectional study using primary data. Subjects were women with pulmonary TB treated in DOTS clinic of Dr. H. A. Rotinsulu Lung Hospital and Center for Community Lung Health (BBKPM) Bandung, from January to February 2023. 40 Subjects were acquired through questionnaire-based interview. This study was conducted on 40 female patients diagnosed with pulmonary TB. The mean age of patients with pulmonary TB was 25.13 years. Before treatment, 50% of patients had normal menstruation, 55% of patients had dysmenorrhea with 37.5% had mild pain, 7.5% of patients had intermenstrual bleeding, 2.5% had secondary dysmenorrhea, and 7.5% had amenorrhea. After treatment, 45% of patients had normal menstruation, 47.5% of patients had dysmenorrhea with 35% experiencing mild pain. In addition, 12.5% had intermenstrual bleeding, 2.5% had secondary dysmenorrhea, and 15% had amenorrhea. Disorders such as frequent/infrequent menstruation, prolonged duration, irregularity, heavy production of blood intermenstrual bleeding, secondary dysmenorrhea, and amenorrhea can be found in pulmonary TB patients both prior and after treatment. There are indeed more findings of patients with abnormal menstruation after the treatment, but with small differences.
ACTIVE SUBSTANCES IN INDONESIAN MEDICINAL PLANTS THAT HAVE ANTIDIABETIC EFFECT A REVIEW
(2021-01-13) ABDAN SYAKURA DANIL; Eko Fuji Ariyanto; Enny Rohmawaty
Diabetes mellitus is the third leading cause of death in Indonesia, around 6.7%, after stroke 21.1%, and coronary heart disease 12.9%. The prevalence of diabetes continues to increase year by year in the world, including Indonesia. Diabetes gives a significant burden for many countries in the world due to the high cost of treatment and reduced productivity of diabetes patients.Comprehensive strategies to prevent and treat diabetes is mandatory. Oral hypoglycemic drugs (OHO) are the first-line therapy for diabetes mellitus patients, however, these oral drugs still have several side effects. Therefore, it is necessary to conduct studies elaborating on medicinal plants with hypoglycemic effects to identify substances that have an antidiabetic effect more resemble physiological processes in the body. Indonesian people often use herbal medicines empirically,but the benefits have not been scientifically well documented. Polyphenol derivatives have been widely studied as hypoglycemic agents that can improve glucose control and increase insulin sensitivity. This paper reviews the hypoglycemic effect of Indonesian medicinal plants such as melinjo seeds (Gnetum gnemon L.), durian plants (Durio zibethinus Murr.), Moringa leaves (Moringa oleifera), and bay leaves (Syzygium polyanthum).
Analisis Data Program Vaksinasi COVID-19 berdasarkan Status Regional Dan Tipe Hari: Sebuah Studi dari Provinsi Jawa Barat, Indonesia
(2023-02-23) PUTRI ADILLA ILHAMI; Mulya Nurmansyah Ardisasmita; Budi Sujatmiko
Vaksinasi adalah strategi untuk mengendalikan pandemi COVID-19 dan berdampak penting terhadap kesehatan global. Pemahaman yang lebih baik mengenai faktor-faktor yang berkaitan dengan vaksinasi diperlukan untuk membentuk program vaksinasi yang baik didalam suatu populasi. Tujuan dari penelitian ini adalah untuk menganalisis data program vaksinasi COVID-19 berdasarkan status regional dan tipe hari di Provinsi Jawa Barat, Indonesia dan berkontribusi untuk menemukan karakteristik lain dari program vaksinasi COVID-19. Studi ini merupakan studi potong lintang dengan menggunakan data sekunder (N=7922) dari Pusat Informasi dan Koordinasi COVID-19 (PIKOBAR) Jawa Barat dari Januari hingga November 2021. Independent T-test dengan alternatif uji non parametrik Mann-Whitney U test (p-value<0,05) digunakan sebagai uji statistik dalam penelitian ini. Hasil penelitian melaporkan adanya perbedaan yang signifikan antara cakupan vaksinasi wilayah kota dan wilayah kabupaten (p<0,001). Perbedaan signifikan antara vaksinasi pada hari kerja dan hari libur juga ditemukan pada kedua wilayah tersebut (p<0,001). Vaksinasi terkonfirmasi lebih tinggi di kota dibandingkan kabupaten dan menurun pada hari libur dibandingkan hari kerja. Penelitian ini menyimpulkan bahwa faktor yang terkait dengan status regional dan tipe hari perlu dipertimbangkan sebagai faktor penting untuk mengembangkan dan mempercepat program vaksinasi.
ANALISIS JUMLAH CEMARAN Escherichia coli PADA TANGAN PENJAMAH MAKANAN DAN PIRING SAJI PANGAN OLAHAN AYAM DI KANTIN FAKULTAS UNIVERSITAS PADJADJARAN
(2023-10-29) MIFTAH NUR RAHMAH YANTI; Siti Nurhasanah; Trianing Tyas Kusuma Anggaeni
Kantin fakultas merupakan fasilitas umum yang menyediakan layanan makan dan minum untuk mahasiswa, dosen, dan tenaga kependidikan. Kantin menjual berbagai macam makanan termasuk pangan olahan ayam. Praktik higiene penjamah makanan dan sanitasi peralatan makan yang kurang diterapkan dengan baik di kantin fakultas, dapat berpotensi menyebabkan makanan terkontaminasi mikroorganisme patogen. Keberadaan bakteri E. coli pada tangan penjamah makanan dan piring saji merupakan indikator kurangnya penerapan higiene dan sanitasi. Penelitian ini bertujuan untuk mengetahui jumlah angka cemaran bakteri E. coli pada tangan penjamah makanan dan piring saji pangan olahan ayam kantin fakultas di lingkungan Universitas Padjadjaran. Jenis penelitian ini adalah penelitian deskriptif dengan analisis laboratorium menggunakan metode Total Plate Count (TPC). Sampel penelitian yaitu tangan penjamah makanan dan piring saji dari 5 kantin fakultas yang memenuhi kriteria inklusi dan eksklusi. Teknik pengambilan sampel yaitu dengan total sampling. Dari 5 sampel tangan penjamah makanan yang diuji, sebanyak 20% mengandung 30 koloni/ml bakteri E.coli. Dari 5 sampel piring saji yang diuji, 20% mengandung 0,2 CFU/cm2 bakteri E.coli dan 80% mengandung bakteri Gram negatif lain. Berdasarkan Peraturan Menteri Kesehatan Republik Indonesia No. 1096/MENKES/PER/VI/ 2011, sebanyak 20% sampel tangan penjamah makanan dan 80% sampel piring saji tidak memenuhi syarat higiene dan sanitasi jasa boga.
ANALISIS KEPATUHAN PENYANDANG HIPERTENSI TERHADAP PENERAPAN 5M SAAT MASA PANDEMI DI JAWA BARAT
(2023-02-16) ALIZHA ROCHANA PUTRI; Nita Arisanti; Muhammad Hasan Bashari
Penyakit Covid-19 telah memberikan dampak secara global bagi kesehatan dan kesejahteraan masyarakat dunia. Bentuk upaya yang dilakukan oleh pemerintah adalah menyuarakan protokol kesehatan 5M meliputi menjaga jarak, mencuci tangan, menggunakan masker, menjauhi kerumunan, dan mengurangi mobilitas. Penyakit komorbid seperti hipertensi dapat meningkatkan kerentanan pada paparan infeksi Covid-19 dan bisa mengakibatkan gejala yang lebih parah. Oleh karena itu, sangat penting untuk diketahui mengenai kepatuhan penyandang hipertensi terhadap penerapan protokol kesehatan 5M. Sebuah penelitian analitik dan komparatif dengan metode pendekatan secara kuantitatif dengan desain studi potong lintang (cross-sectional) dilakukan pada bulan Agustus 2021. Responden adalah penyandang hipertensi yang berdomisili di kabupaten (n=109) dan kota (n=51) daerah Jawa Barat. Data dikumpulkan dengan kuesioner secara daring. Secara total, penelitian ini mendapatkan hasil persentase kepatuhan lebih tinggi di kota (66,7 %) dibandingkan di kabupaten (41,3%) pada provinsi Jawa Barat.
ANALISIS KUALITATIF DAMPAK PANDEMI COVID-19 TERHADAP PELAYANAN PRAKTIK DOKTER HEWAN DI KOTA BANDUNG
(2018) DIANITA GUSTINA; Tyagita; Noormarina Indraswari
Peningkatan jumlah kasus COVID-19 di Kota Bandung menyebabkan terjadinya perubahan pada pelayanan kesehatan, salah satunya adalah pelayanan kesehatan hewan. Penelitian ini bertujuan untuk mengetahui dampak pandemi COVID-19 serta upaya yang dilakukan dokter hewan dalam menghadapi dampak pandemi COVID-19 di klinik. Pengumpulan data kualitatif diperoleh dengan cara mengumpulkan data primer melalui wawancara mendalam (indepth interview) dan obeservasi. Pengumpulan data dilakukan terhadap informan yang dipilih untuk mendapatkan jawaban dan menggali informasi tentang dampak dan upaya yang dilakukan selama pandemi pada setiap layanan praktik dokter hewan. Dampak yang ditemukan diantaranya, yaitu terjadi kelangkaan obat-obatan, terinfeksinya petugas klinik oleh COVID-19, penutupan sementara klinik hewan, kekurangan tenaga medis, penurunan jumlah pasien pada masa awal pandemi COVID-19, dan peningkatan jumlah pasien pada masa adaptasi kebiasaan baru. Kemudian terdapat upaya yang dilakukan untuk menghadapi dampak tersebut diantaranya, yaitu penerapan protokol kesehatan, perubahan jadwal operasional, perubahan alur pelayanan, pemberian layanan online atau telemedicine, penggunaan APD pada petugas medis, pembatasan tindakan operasi, pembatasan jumlah pasien, penyediaan obat-obatan dalam jangka waktu panjang, pertukaran jadwal istirahat petugas klinik, penambahan jumlah poli pemeriksaan, pelaksanaan disinfeksi rutin, serta anjuran melakukan vaksinasi COVID-19 dan menjaga imunitas tubuh kepada petugas klinik hewan.
ANALISIS PEMBIAYAAN JAMINAN KESEHATAN NASIONAL (JKN) PADA PASIEN DIABETES MELLITUS TIPE 1 DAN TIPE 2 DI FASILITAS KESEHATAN RUJUKAN TINGKAT LANJUT (FKRTL) JAWA BARAT TAHUN 2015-2020
(2023-02-19) TALITHA ZADA NURZAHIRA; Elsa Pudji Setiawati Sasongko; Irvan Afriandi
Diabetes Mellitus (DM) di Jawa Barat pada tahun 2015-2020 memiliki angka prevalensi yang terus meningkat dan ditangani baik di Fasilitas Kesehatan Tingkat Pertama (FKTP) ataupun di Fasilitas Kesehatan Rujukan Tingkat Lanjut (FKRTL). Diabetes Mellitus merupakan salah satu penyakit yang pembiayaan pengobatannya ditanggung oleh Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan. Penelitian bertujuan untuk mengetahui gambaran pembiayaan pengobatan DM di FKRTL. Penelitian menggunakan desain deskriptif kuantitatif. Data yang digunakan merupakan data tersier, yaitu data sampel Kontekstual Diabetes Mellitus BPJS Kesehatan 2015-2020. Subyek penelitian merupakan pasien DM yang menerima pelayanan di Fasilitas Kesehatan Rujukan Tingkat Lanjut (FKRTL) Jawa Barat Tahun 2015-2020. Keseluruhan data telah dianalisis dengan menggunakan pembobotan yang tertera pada data sampel. Hasil dari penelitian menunjukkan bahwa terdapat 8346 pasien dengan diagnosis DM tipe 1 dan tipe 2 dengan mayoritas perempuan berusia 60-64 tahun dan segmen Peserta Bukan Penerima Upah. Karakteristik klinis dari data pasien DM tipe 1 dan 2, yaitu kunjungan pasien lebih banyak ke rumah sakit dengan jenis kunjungan rawat inap dibandingkan dengan rawat jalan, dengan status pulang sehat, tingkat keparahan ringan dan kelas rawat 1. Pembiayaan DM oleh BPJS secara umum sudah sesuai dengan yang ditagihkan, kecuali pada pembiayaan kunjungan rawat inap Klinik Utama pasien DM tipe 2 pada tahun 2018.
Analisis Penerapan Higiene dan Sanitasi Rumah Potong Hewan di Desa Sagaracipta Kecamatan Ciparay Kabupaten Bandung
(2023-08-11) AGNES AGUSTIN; Okta Wismandanu; Kuswandewi Mutyara
Rumah Potong Hewan (RPH) merupakan salah satu sarana untuk menghasilkan daging yang aman, sehat, utuh, dan halal (ASUH), namun jika tidak mendapatkan penanganan yang baik maka daging mudah rusak, sehingga terdapat beberapa hal yang perlu diperhatikan, yaitu penerapan higiene dan sanitasi. Tujuan penelitian ini adalah untuk mengetahui penerapan higiene personal, kondisi sanitasi dan fasilitas bangunan, serta persepsi pekerja mengenai penerapan higiene dan sanitasi di RPH. Penelitian ini dilakukan di RPH di Desa Sagaracipta dan data diperoleh dari 7 informan dengan melakukan observasi dan wawancara. Data observasi dianalisis secara deskriptif dan data hasil wawancara dianalisis dengan Nvivo 12 Plus. Hasil penelitian menunjukkan beberapa persyaratan higiene telah terpenuhi, seperti pemakaian sepatu boots dan pakaian kerja, dan beberapa persyaratan sanitasi telah terpenuhi, seperti lokasi RPH yang tidak rawan bencana, jauh dari daerah industri, memiliki air yang cukup, sarana jalan yang baik, terdapat kendaraan pengangkut, dan peralatan yang tidak korosif, sedangkan beberapa persyaratan higiene yang tidak terpenuhi adalah kurangnya kebiasaan mencuci tangan dengan sabun, tidak adanya pelatihan pekerja, terdapat pekerja yang tidak memakai sarung tangan, masker, penutup kepala, dan apron, dan kurangnya kesadaran pekerja terhadap penerapan higiene, dan beberapa persyaratan sanitasi yang tidak terpenuhi adalah lokasi yang berdekatan dengan pemukiman, permukaan lantai, dinding, dan langit-langit yang memiliki celah, tidak terdapat sarana pengelolaan limbah, dan tidak terdapat sarana cuci tangan khusus.
ANALISIS RUJUKAN OBSTETRI BERDASARKAN LEVEL KEPARAHAN DI RSUP DR. HASAN SADIKIN BANDUNG PERIODE 2019-2021 PRE-PANDEMI DAN MASA-PANDEMI
(2023-02-16) HANIF AL MAJIDAN; Windi Nurdiawan; Dini Pusianawati
Tujuan: Penelitian ini menentukan angka keberhasilan penanganan kasus rujukan severity level II dan III pasien kandungan di RSHS periode 2019-2021. Mengetahui hubungan antara usia, frekuensi ANC, asal rujukan, penolong pertama sebelum rujuk, dan lama perawatan terhadap keberhasilan penanganan pasien kandungan. Mengetahui pengaruh pandemi covid-19 terhadap keberhasilan rujukan obstetri dan frekuensi ANC severity level II dan III di RSHS Metode: Penelitian analitik terhadap pasien kandungan di RSHS pada periode Maret 2019 - April 2021. Subjek pasien rawat inap severity level II dan III dikategorikan oleh sistem INA-CBGs. Jumlah sampel minimal dihitung berdasarkan rumus Snedecor dan Cochran severity II dan III masing-masing 32 dan 81 orang. Uji menggunakan chi-square dan Mann-whitney (CI 95%, p >0,05). Hasil: Pasien rujukan obstetri 2019-2021 keberhasilan rujukan severity level II 93,75% dan severity level III 81,81%. Pada pasien severity level III masa-pandemi 2019 terdapat hubungan yang signifikan (p = 0,038) antara usia ibu hamil dengan kematian. Pada severity level III, ada pengaruh yang signifikan antara pandemi covid-19 dengan penurunan keberhasilan rujukan (p = 0,027). Kesimpulan: Keberhasilan yang baik tercapai pada penanganan kasus pasien kandungan dengan severity level II dan III periode 2019-2021 dibandingkan hasil rujukan tahun sebelumnya 2017-2018. Dari penelitian kami ada hubungan antara usia ibu hamil dan pandemi dengan kematian pada rujukan severity level III.
Angka dan Karakteristik Klinis Pasien Infeksi Jamur Invasif di RSUP Dr. Hasan Sadikin Tahun 2020 - 2022
(2023-07-14) ARIELLA ALESSANDRO; Nisa Fauziah; Intan Mauli Warma Dewi
Pendahuluan. Infeksi jamur invasif merupakan sekelompok jenis infeksi jamur dengan mortalitas tinggi yang masih terbengkalai. Penelitian ini dilakukan untuk mengetahui angka kejadian dan karakteristik klinis pasien infeksi jamur invasif yang dirawat di RSUP Dr. Hasan Sadikin. Metode. Penelitian menggunakan metode deskriptif dengan pendekatan potong lintang berupa data sekunder rekam medis dari pasien yang pernah terdiagnosis infeksi jamur invasif pada tahun 2020 – 2022 di RSUP Dr. Hasan Sadikin. Jumlah sampel ditentukan dengan metode total sampling. Hasil. Penelitian ini menunjukkan bahwa prevalensi infeksi jamur invasif di RS Hasan Sadikin pada tahun 2020-2022 adalah 0,04%. Penyebab infeksi jamur invasif terbanyak dari 35 sampel yang diperoleh adalah Cryptococcus spp. dan Candida spp. Tanda dan gejala klinis yang paling sering muncul adalah demam dan penurunan kesadaran. Terdapat 18 pasien yang merupakan penderita HIV/AIDS. Pemeriksaan penunjang yang paling sering dilakukan adalah pemeriksaan cryptococcal antigen (CrAg). Pasien dengan keterlibatan paru-paru juga banyak ditemukan, dengan gambaran radiologi mencakup konsolidasi, infiltrat, dan opasitas ground glass. Angka kematian pasien dari penelitian ini adalah 51,43%. Simpulan. Prevalensi penyakit jamur invasif di RSUP Dr. Hasan Sadikin cukup rendah dan paling sering terjadi pada pasien HIV/AIDS. Meskipun demikian, angka kematian dari infeksi jamur invasif cukup tinggi. Penegakkan diagnosis dini secara definitif serta pemberian obat antijamur yang tepat penting dilakukan untuk memperbaiki outcome pasien infeksi jamur invasif. Kata Kunci: Infeksi jamur invasif, Penyakit jamur invasif
Anti-Migration Effect of Aaptamine on HCC-1954 HER2 Positive Breast Cancer Cells
(2023-07-14) KANIA ADELIA HESTY KIRANI; Resti Gradia Dwiwina; Muhammad Hasan Bashari
Objective : This study aims to analyze aaptamine’s antimigration effect against HCC-1954 cell line, a trastuzumab-resistant HER2 positive breast cancer cells, through wound healing assay. Methods : HCC-1954 HER2 positive breast cancer cells. Aaptamine (8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine). MTT Assay were done to assess cytotoxicity of aaptamine. Wound healing assay is used to determine antimigration effect. Results : This study shows aaptamine’s capability of antimigration effect. Gap closure is compared between control group and IC5, IC10, and IC25 at 72 hours. Compared to control, results show migration area is smaller at IC25, but bigger at IC5 and IC10 though not significantly. Conclusion : Aaptamine inhibits HCC-1954 migration at IC25 though not statistically significant from control group.
Artificial Intelligence in Psychiatry: A Qualitative Study of Gen Z in Indonesia
(2023-07-13) SABRINA NURHIDAYAH; Irma Ruslina Defi; Shelly
Background: Artificial intelligence (AI) in psychiatry is increasingly being developed worldwide to help overcome the rising prevalence of psychiatric disorders, especially among Generation Z, but its potential remains questionable. Objective: This study aims to understand and explore the perceptions of Generation Z towards using AI in the psychiatric field and its potential to develop in Indonesia. Methods: The study is conducted using an online survey via Google Forms involving 36 undergraduate students spread across 18 universities in Indonesia. This study conducted a thematic analysis of responses that answered seven open-ended questions regarding respondents’ prior knowledge, opinions on the advantages, disadvantages, and the capacity of AI to replace the role of psychiatrists, and the development potential of AI in psychiatry in psychiatry in Indonesia. Results: Most respondents mentioned that AI could help psychiatrists in the screening and diagnosing process, while the least mentioned is in giving therapy. Accessibility and efficiency are the most mentioned advantages of AI in psychiatry, followed by its technical advantages and its ability to minimize human error. At the same time, lack of empathy and reliability issues are the most mentioned disadvantages of AI in psychiatry, followed by interaction barriers and the probability of system error. AI in psychiatry is mentioned to be well-developed in the future, with resources, infrastructures, and government supports becoming the factors that can affect its development. Conclusion: Understanding Generation Z`s perceptions of AI in psychiatry is essential to maximize the potential of AI usage and development in the future of the psychiatric field. Gen Z gives divergent views of AI’s value and impact in psychiatry with worrying omissions about safety issues, regulations, and practice guidelines.
Association Between Anemia and Urinary Tract Infection With APGAR Score of Preterm Birth in Hasan Sadikin Hospital 2021-2022
(2023-07-14) SITI NADYA KHAIRUNISSA ALAMSYAH; Windi Nurdiawan; Mulya Nusa Amrullah Ritonga
Purpose: To find the correlation between anemia and urinary tract infection with outcomes of preterm birth that is valued by APGAR score. Patients and Methods: This is an observational analytic study with cross-sectional approach. Sampling method conducted by consecutive sampling. This study used 338 patient medical records in Hasan Sadikin Hospital, Bandung. This study held on March-May 2023. The data collected were statiscally analyzed by the Chi-Square and logistic regression method. The data analysis is conducted by statistic software (Microsoft® Excel 2022 and IBM® SPSS® version 18). Results: Apgar scores in infants of anemic patients were dominated by mild-moderate asphyxia (30.3%) (p<0.001) and severe asphyxia (28.8%) (p<0.001). Then, the Apgar scores in infants of patients with urinary tract infections were dominated by mild-moderate asphyxia (11.8%) (p<0.001) and severe asphyxia (6.3%) (p<0.001). Furthermore, the Apgar scores in infants of patients with anemia and UTI were dominated by mild-moderate asphyxia (22.2%) (p<0.001) and severe asphyxia (55.6%) (p<0.001). Conclusion : There is a significant correlation between anemia and preterm birth outcomes (p<0.001, PR 9,78 ;95%), urinary tract infection (UTI) and preterm birth outcomes (p<0.001, PR 6,77 ;95%), and anemia and UTI and preterm birth outcomes (p<0.001, PR 23,71 ;95%).
Association between Comorbidities and COVID-19 in Pregnant Women at Dr. Hasan Sadikin General Hospital Bandung 2020-2021
(2023-02-15) VISCHILA GERAY D'LAMANDA; Lulu Eva Rakhmilla; Amillia Siddiq
Objective: The study aimed to determine the association between comorbidities and COVID-19 in pregnant women at Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia. Methods: We conducted a cross-sectional study between January 2020 and December 2021 involving 278 women aged 16-45 years, at Dr.Hasan Sadikin General Hospital, Bandung, Indonesia, which serves as the main West Java tertiary hospital and COVID-19 referral hospital. We collected information from the medical record on comorbidities such as hypertension, obesity, diabetes mellitus, and others. Logistic regression models were fitted, and odds ratios with 95% confidence intervals (OR, 95%CI) were estimated. Result: Of the 278 data included in this study, 120 cases had comorbidities. Most patients were asymptomatic, 82%. Obesity is the most common comorbid proportion, 71%. Only hypertension comorbid showed a significant association with symptomatic or asymptomatic COVID-19 (p<0.05). Pregnant women with hypertension were six times more likely to show symptoms than those without hypertension. (Odds ratio 6.092; 95% CI, 3.103-11.962). Pregnant women with obesity were 1.8x more likely to show symptoms than those without obesity (Odds ratio 1.856; 95% Confidence Interval, 0.987-3.489). Pregnant women with comorbidities were at higher risk of cesarean section 55% and stillbirth 67%. Conclusion: The domination of asymptomatic COVID-19 in pregnant women was found in this study. Hypertension comorbid has a significant association with COVID-19 symptoms. Maternal and neonatal outcomes appear to be influenced by maternal comorbidities.
ASSOCIATION BETWEEN NUTRITIONAL STATUS, STRESS AND DIETARY HABIT DURING COVID-19 PANDEMIC AMONG ADULTS IN BANDUNG
(2023-07-13) RYAN MARIO CHRISTIAN; Bony Wiem Lestari; Nanny Natalia Mulyani Soetedjo
Background: The COVID-19 pandemic brought impact to stress and eating habit. Nutritional status changes might be linked to stress and eating habit. Unhealthy nutritional status could present major health risks and should be prevented. The aim is understanding the characteristics of population and determining the relation between stress, eating habit and nutritional status. Methods: A cross-sectional analytical study was done on January 2023 with secondary data from another study by Soetedjo et al. The sample is comprised of 105 adults in Bandung from 10 regions were taken using proportionate sampling. Data were taken using General Health Questionnaire-12 (GHQ-12), Eating Habit Questionnaire, stadiometer, weight scale, and clinical measuring tape. Association of stress and eating habit with waist circumference, and stress with eating habit was analysed using Chi Square. Association of eating habit with waist circumference used Fisher’s Exact test. Association of stress and eating habit with body mass index was analysed using Mann-Whitney test. Result: This subjects are consisted of 52 male and 53 female. Stress was reported in 26.7% and waist circumference corresponding to central obesity was reported in 25.7% of subjects. Distribution of respondents by BMI was 9.52% underweight, 48.57% normal, 22.86% pre-obesity, 10.48% obese-1, and 8.57% Obese-2. Significant association between stress and Waist Circumference (p=0.003) was found indicating higher stress level is associated with abnormal waist circumference. Conclusion: The significant association between stress and waist circumference suggest that stress is one of the factors affecting waist circumference and subjects who’re distressed during COVID-19 pandemic tends to have abnormal waist circumference. This may indicate that stress is a factor
Association of BRAF p.Val600Glu and KRAS Mutations with Clinicopathologic Characteristics Among Colorectal Cancer Patients in a Tertiary Hospital in West Java, Indonesia
(2023-02-20) AHMAD NAUFAL ALFARISY; Yunia Sribudiani; Reno Rudiman
Background: The colorectal cancer (CRC) remains a major burden in cancer worldwide, ranking third and second in incidence and mortality respectively. Detection of biomarkers including BRAF p.Val600Glu and KRAS mutations can help in predicting prognosis and response to therapy in CRC. This study aims to evaluate frequency of BRAF p.Val600Glu and KRAS mutations among Indonesian patients and their associations with patients clinicopathologic characteristics. Methods: 53 CRC samples were collected from January to September 2022 in the Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. BRAF p.Val600Glu and KRAS mutations were analyzed using PCR followed by Sanger sequencing. Associations between BRAF p.Val600Glu and KRAS mutations were evaluated using Pearson`s chi-squared test. Result: None of the samples were positive BRAF V600E mutation. KRAS mutations were detected in 52.8% patients (n=28), of which 3.6% were p.Gly12Ser (n=1), 32.1% were Gly12Asp (n=9), 7.1% were p.Gly13Asp (n=2), 3.6% were p.Gln61His (n=1), 3.6% were p.Asp126His (n=1), 3.6% were p.Lys169Glu (n=1), and polymorphism of p.Asp73= were detected in 57.1% of the samples (n=16). KRAS mutation status was not associated with age of onset, sex, tumor location, tumor histology, and , family history. Conclusion: BRAF p.Val600Glu mutations were not observed in this study, while KRAS mutations were present in high frequency. KRAS mutations status do not associate with age of onset, sex, tumor location, tumor histology, and family history.
Associations Between Obesity and Quality of Life and Academic Performance Among Late Adolescents In Jatinangor
(2023-02-16) SALWA VISKA NADLIRA; Rodman Tarigan; Tisnasari Hafsah
Background. The prevalence of obesity in children and adolescents is increasing and it impacts their quality of life. The late adolescent stage (aged 16-19 years) is critical since it marks the beginning of adulthood as well as independence and responsibility. This study aimed to determine whether obesity impacts the quality of life and academic performance of late adolescents in Jatinangor. Methods. This observational cross-sectional study of senior high school students in Jatinangor was conducted from August to September 2022. Their quality of life was assessed using the Indonesian version of the PedsQL (Pediatric Quality of Life Inventory) 4.0 Generic Scale report on adolescents aged 13-18. Academic performance was assessed from the student`s last semester report score. Results. There was no association between obesity and quality of life (p=0.691; CI=0.441 – 3.435) or academic performance (p=0.089; OR=0.396; CI=0.136 – 1.151). Physical activity and sleep duration were significantly associated with quality of life (p=0.006 and p=0.001, respectively), while academic performance was significantly influenced by gender (p=0.001) and physical activity (p=0.002). Based on the Mentel-Haenszel test, physical activity affected the relationship between obesity and quality of life (p=0.036) and is a confounding factor for the relationship between obesity and academic performance (p=0.474). Conclusion. There was no association between obesity and quality of life or academic performance but physical activity affected both quality of life and academic performance.
BLENDED LEARNING ADAPTATION OF MEDICAL PROFESSION STUDY PROGRAM DURING THE COVID-19 AT FACULTY OF MEDICINE, UNIVERSITAS PADJADJARAN IN 2021
(2018) NAUFAN ALPHA HARIZ; Agung Dinasti Permana; Shinta Fitri Boesoirie
Background: The Indonesian government has shifted teaching and learning activities to online to prevent COVID-19 transmission. Still, clinical skills practice in hospitals is compulsory for medical students. They could not apply online learning 100%, so blended learning is applied. The blended learning system is a new thing in the Medical Profession Study Program, Faculty of Medicine, Universitas Padjadjaran, and no research describes it yet. The purpose of this study was to find out a description of the adaptation of blended learning during the COVID-19 pandemic based on students’ perceptions. Methods: This study used a closed “yes/no” questionnaire. Twenty-one questions prepared following blended learning guides were distributed randomly (simple random sampling) to Medical Profession Study Program students’ (class of 2020 and 2021) at the Faculty of Medicine, Universitas Padjadjaran, from December 2021 to January 2022 (n=261). Students who do not participate in the blended learning system will be excluded from the study. Meanwhile, active students from the class of the 2020-2021 period who are willing to be respondents will be included. Results: The results showed that most students were aware of the adaption of blended learning (yes > 50%). The highest percentage of "yes" answers was the question about students` awareness of virtual face-to-face learning activities (Virtual Synchronous) (98.95%). Meanwhile, the lowest percentage of "yes" answers was the question about the students` perceptions regarding the application of a structured schedule (during working hours) (38.31%). Conclusions: Blended learning during the COVID-19 pandemic from the students’ point of view is already per the decree and guidebooks. The structured schedule experienced by the students was not fully implemented during working hours. Keywords: blended learning, COVID-19, learning adaptation, Medical Profession Study Program, student perception
Bone Age Description of Carpal Bones in Short Stature Children Treated at Dr. Hasan Sadikin General Hospital Bandung in 2020-2021
(2023-02-20) BURHANUDDIN; Harry Galuh Nugraha; Novina
Background: The purpose of this study was to determine the description of bone age in the carpal bones of children of short stature who were treated at the Department of Pediatrics, Dr. Hasan Sadikin General Hospital Bandung in 2020-2021. Methods: This study is a descriptive observational study with a cross-sectional design conducted from January 2020 to December 2021. A total of 6,370 patient`s data in 2020 and 6,248 in 2021 were obtained from Dr. Hasan Sadikin General Hospital medical records. This study included 323 pediatric patients who were diagnosed with short stature and 36 patients with bone age examination that have been selected based on the inclusion and exclusion criteria. The analyzed variables are gender, birth history, underlying disease, therapy history, height to age, and bone age. Results: The prevalence of patient with short stature in 2020 is 185 (2.90%) and 2021 is 138 (2.21%). Gender distribution showed 164 (50.77%) males and 159 (49.22%). There are 36 data with bone age examination, which all of them categorized as delayed. In patients with delayed bone age, 25 (69.44%) of them diagnosed with severely stunted and 11 (30.56%) of them are stunted. Conclusion: Patients diagnosed with short stature in 2020 to 2021 has no significant difference in gender, but predominantly in male patients. All patients with bone age examination categorized as delayed bone age. Length/height for age category showed most patient has short stature.

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